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KMID : 0356420020200020094
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Journal of Korean Andrology
2002 Volume.20 No. 2 p.94 ~ p.99
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Effect of Panax Ginseng Water Extract for Treatment of Male Infertility
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Kim Yong-Tae
Lee Hyung-Lae
Lee Sang-Cheol
Shin Kwan-Hee
Han Kwang-Hee
Lee Seung-Chan
Jang Hoon
Kim Tae-Hwan
Kim Wun-Jae
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Abstract
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Purpose: We previously reported that Panax ginseng water extract (PG-WE) played both preventive and therapeutic roles on testicular toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in animal study, one of the most potent environmental pollutants. Thus we investigated whether PG-WE might be useful in the treatment of male infertility, because men in modern society are exposed by numerous environmental hormones.
Materials and Methods: Eighteen patients with abnormal semen analysis and 8 volunteers whose semen analysis were normal as control group were enrolled in this study. Before PG-WE administration, semen analysis, hormonal study, liver and renal function test, CBC, and urinalysis were checked in all subjects. PG-WE (2.4 gm) was administered everyday for 8 weeks in both groups. Follow-up semen analysis and laboratory studies were checked at 13th week.
Results: In patient group semen volume was increased (2.4+-1.3 ml vs 2.6+-1.6 ml, p=0.051). Semen volume as well as sperm concentration in oligospermia patient were increased but not significantly. Serum estradiol level decreased by PG-WE treatment in patient group (p=0.005). All subjects showed no toxic effect.
Conclusions: Our data suggest that Panax ginseng is a potential agent that can improve abnormal sperm parameters in infertile male patients and also improve the sperm quality in healthy men.
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KEYWORD
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Panax ginseng water extract, Infertility
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